[89], BisphenolA's interacts with the estrogen-related receptor (ERR-). BPA is a structural component in polycarbonate beverage bottles. An official website of the United States government. bisphenol A (BPA), a colourless crystalline solid belonging to the family of organic compounds; its molecular formula is C 15 H 16 O 2. Per the diagram below, most epoxy resins are made by reacting Bisphenol A (BPA) with an excess of epichlorohydrin so the end groups are glycidyl ethers. 133 Cecil Street, All rights reserved, 2,2-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bis[oxirane],homopoly, 4,4-(1-methylthylidene)bisphenol,polymerwith2,2-[(1-methylethylidene)bis(, Poly(Bisphenol A-co-epichlorohydrin) average Mw ~40,000, pellets, 4-(1-methylethylidene)bisphenol,-polymerwith(chloromethyl)oxirane, bis(4,1-phenyleneoxymethylene)]bis[oxirane], diglycidyletherofbisphenola-basedepoxyresins,lowmolecularweight, lowmolecularweightliquiddgebpa-basedepoxyresins, lowmolecularweightsoliddgebpa-basedepoxyresins, Phenol,4,4-(1-methylethylidene)bis-,polymerwith(chloromethyl)oxirane, phenol,4,4-isopropylidenedi-,dimerwith1-chloro-2,3-epoxypropane, phenol,4,4-isopropylidenedi-,monomerwith1-chloro-2,3-epoxypropane, phenol,4,4-isopropylidenedi-,polymerwith1-chloro-2,3-epoxypropane, phenol,4,4-isopropylidenedi-,tetramerwith1-chloro-2,3-epoxypropane, 2,2-Bis(p-hydroxyphenyl)propane-epichlorohydrin condensate, 2,2-Bis(p-hydroxyphenyl)propane-epichlorohydrin copolymer, 2,2-Bis(p-hydroxyphenyl)propane-epichlorohydrin polymer, 2,2-Diphenylolpropane-epichlorohydrin polymer, 4,4'-ISOPROPYLIDENEDIPHENOL/EPICHLOROHYDRIN COPOLYMER, 4,4-ISOPROPYLIDENEDIPHENOLEPICHLOROHYDRINRESIN, PHENOL44METHYLETHYLIDENEBISPOLYMERWITHCHLOROMETHYLOXIRANE, Reaktionsprodukt aus Bisphenol-A oder -F mit Epichlorhydrin (Molekulargewicht <700, Gehalt an freiem Epichlorhydrin <20 ppm, nicht in R40 oder R45 eingestuft), reaction product: bisphenol-A-(epichlorhydrin) epoxy resin (number average molecular weight 700), bisphenol A/ epichlorohydrin resin, solid, bisphenol A/ epichlorohydrin resin, liquid, BISPHENOL A DIGLYCIDYL ETHER RESIN structure, EPICHLOROHYDRIN-4,4'ISOPROPYLIDENEDIPHENOL RESIN, Bisphenol A epichlorohydrin polymer (25068-38-6), P201-P273-P280-P305+P351+P338-P310-P333+P313-P337+P313-P391, 36/38-43-51/53-42/43-63-62-36/37-20/21/22-45-23/24/25, BISPHENOL A DIGLYCIDYL ETHER RESIN Suppliers, BISPHENOL A DIGLYCIDYL ETHER RESIN(25068-38-6)FT-IR, TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III), 4-[1-hydroxy-2-(4-hydroxyphenyl)propan-2-yl]phenol, 4-[2-(4-hydroxyphenyl)propan-2-yl]phenol: 2-methyloxirane, 4-[1,1,1,3,3,3-Hexafluoro-2-(4-hydroxyphenyl)propan-2-yl]phenol, Phenol, 4,4-(1-methylethylidene)bis-, polymer with (chloromethyl)oxirane, monoesters with C18-unsatd. . Toxicol Lett. [5] https://www.regulations.gov/docket/FDA-2010-N-0100. This compound is synthesized by the condensation of acetone with phenol. [1]U.S. Food and Drug Administration, Draft Assessment of Bisphenol A for Use in Food Contact Applications, 14 August 2008. . Reprod Toxicol. Lactational transfer of bisphenol A in Sprague-Dawley rats. You can also browse global suppliers,vendor,prices,Price,manufacturers of Bisphenol A epoxy resin(). Chemical compound used in plastics manufacturing, InChI=1S/C15H16O2/c1-15(2,11-3-7-13(16)8-4-11)12-5-9-14(17)10-6-12/h3-10,16-17H,1-2H3, InChI=1/C15H16O2/c1-15(2,11-3-7-13(16)8-4-11)12-5-9-14(17)10-6-12/h3-10,16-17H,1-2H3, Except where otherwise noted, data are given for materials in their, "Chemical Fact Sheet Cas #80057 CASRN 80-05-7", Ullmann's Encyclopedia of Industrial Chemistry, "Critical evaluation of key evidence on the human health hazards of exposure to bisphenol A", "Why public health agencies cannot depend on good laboratory practices as a criterion for selecting data: the case of bisphenol A", "The Estrogen Receptor Relative Binding Affinities of 188 Natural and Xenochemicals: Structural Diversity of Ligands", "Bisphenols, Benzophenones, and Bisphenol A Diglycidyl Ethers in Textiles and Infant Clothing", "Pit and fissure sealants for preventing dental decay in permanent teeth", "Bisphenol S in Food Causes Hormonal and Obesogenic Effects Comparable to or Worse than Bisphenol A: A Literature Review", " i ", "Condensationsproducte aus Ketonen und Phenolen", "The politics of plastics: the making and unmaking of bisphenol a "safety", "Synthetic strogenic Agents without the Phenanthrene Nucleus", "Molecular Structure in Relation to Oestrogenic Activity. From durable sneakers to waterproof jackets, chemistry plays a big role in all types of outdoor activities. The safety of a food additive is not relevant to FDAs determination regarding whether a certain use of that food additive has been abandoned. Transfer to a pear-shaped separatory funnel to separate the liquid, continue washing and separating with deionized water until the solution turns to neutral from alkaline. Therefore, they are effective adhesion for most substrates such as glass, ceramics, silicon wafers, and polymer materials. and epichlorohydrin. It belongs to the phenol class of aromatic organic compounds. EC number: 500-130-2 [9][10] The manufacturing of epoxy resins and vinyl ester resins account for 2530% of BPA use. BPA is one of the most thoroughly tested chemicals in use today and has a safety track record of more than 50 years. BPA Initiatives - The National Institute of Environmental Health Sciences (NIEHS) and National Toxicology Program (NTP) have developed an integrated, multipronged, consortium-based approach to optimize BPA-focused research investments to more effectively address data gaps and inform decision making. To fix the amount of fixed bisphenol A and make excess epichlorohydrin can obtain DGEBA. Polycarbonate plastic is a lightweight, high-performance plastic that possesses a unique balance of toughness, optical clarity, high heat resistance, and excellent electrical resistance. [92][101][102] Its half life in water has been estimated at between 4.5 and 15 days, degradation in the air is faster than this, while soil samples degrade more slowly. Other Details: - Bisphenol resin is extensively used with consumer products such as applying coatings inside of food and beverage cans as this leave no bad effects or any risk of hazard to human health. Among the non-food sources, exposures routes include through dust,[10] thermal paper,[20] clothing,[19] dental materials,[69] and medical devices. Every day, people are exposed to a variety of activities or products that could, under certain circumstances, cause harm. FDA can make regulatory changes based on new safety or usage information. On this Wikipedia the language links are at the top of the page across from the article title. In order to formulate an epoxy adhesive, one must have either bisphenol A or bisphenol F. Bisphenol A (BPA) is generally preferred for its curing properties. [90] Different expression of ERR- in different parts of the body may account for variations in bisphenolA effects. People are generally exposed to minute levels of BPA, mostly from the ingestion of food or beverages that have been in contact with materials manufactured with BPA. More than 140,000 products, 270,000 supply sources and 4,400 company addresses. . . Dianin in 1891. The epoxide resins (also widely known as epoxy resins and, occasionally, as ethoxyline resins) are characterised by the possession of more than one 1,2-epoxy group (I) per molecule. Heightened interest in the safe use of BPA in food packaging has resulted in increased public awareness as well as scientific interest. Properties of copolymer epoxy resins. Due to interest in the exposure to bisphenol A in the community1 and the workplace, OSHA developed a validated method to collect and analyze bisphenol A and diglycidyl ether of bisphenol A. just looking for general information about environmental health research or the institute, this page will help. Whether you're producing perfume or PVC plastics, the chances are intermediates will . Farbenindustrie reported the coupling of BPA and epichlorohydrin. Its optical clarity allows direct observation of blood or other fluids to monitor proper flow. tableware. Bisphenol-F can further link generating tri- and tetra-and higher phenol oligomers. Polym Adv Technol 2009; 20: 194-208. . The chemical formula of Bisphenol A isC15H16O2. When the low-molecular-weight bisphenol A epoxy resin is continuously reacted with bisphenol A, the obtained bisphenol A epoxy resin has a high polymerization with a relative molecular mass 1400 or more. Phenol-formaldehyde resin . [5] Although the reassessments indicated a need to further evaluate a number of endpoints or biological outcomes, the analyses did not recommend any adjustments to BPA levels reported in food at that time. PubChem CID 24754; . Based on FDAs ongoing safety review of scientific evidence, the available information continues to support the safety of BPA for the currently approved uses in food containers and packaging. Hot Sale CAS No 80-05-7 BPA Solid Bisphenol a for Epoxy Resin Price in Stock FOB Price: US$ 1900-2200 / Ton Min. The results of the CLARITY Study, a 5+ year, multipronged U.S. federal government research program and the largest study ever done on BPA, confirm BPAs safety. [28] BPA was never used as a drug. [35][34], BPA has a fairly high melting point but can be easily dissolved in a broad range of organic solvents including toluene, ethanol and ethyl acetate. Concerns about the health effects of BPA have led some manufacturers replacing it with other bisphenols, such as bisphenol S and bisphenol F. These are produced in a similar manner to BPA, by replacing acetone with other ketones, which undergo analogous condensation reactions. Since that time, the FDA has continued to review additional studies as they became available, including those addressing possible low-dose effects. The internal rotation function of the ether bond increases the flexibility of the molecule, and the hydroxyl group enhances the chemical reactivity and the bonding ability, the epoxy group cross-links molecules into a three-dimensional network structure by reacting with a curing agent. Demonstrated that oral BPA administration results in rapid metabolism of BPA to an inactive form. In 2008 FDA released a document titled Draft Assessment of Bisphenol A for Use in Food Contact Applications. [37] Crystals form in the monoclinic space group P 21/n (where n indicates the glide plane); within this individual molecules of BPA are arraigned with a 91.5 torsion angle between the phenol rings. The National Institute of Environmental Health Sciences (NIEHS) is expanding and accelerating its contributions to scientific knowledge of human health and the environment, and to the health and well-being of people everywhere. Polycarbonate is strong and durable, but over time it may break down from over use at high temperatures. 2013 Jul 1;270(1):45-59. BPA is an industrial chemical used to make polycarbonate, a hard, clear plastic, which is used in many consumer products. The .gov means its official. Durable and decorative floorings, such as terrazzo flooring, chip flooring and colored aggregate flooring, are made from epoxy resins. Recalls, Market Withdrawals and Safety Alerts, Substances Added to Food (formerly EAFUS), Bisphenol A (BPA): Use in Food Contact Application, Summary of FDAs Current Perspective on BPA in Food Contact Applications, Overview of BPA Usage in Food Contact Applications, Increasing Our Understanding about the Biology and Metabolism of BPA, Food Additive Regulations Amended to No Longer Provide for the Use of BPA-Based Materials in Baby Bottles, Sippy Cups, and Infant Formula Packaging, based on its most recent safety assessment, Final report for the review of literature and data on BPA, 2014 Updated Review of Literature and Data on Bisphenol A, 2012 Updated Review of Literature and Data on Bisphenol A, Updated Review of the Low-Dose Literature (Data) on Bisphenol A and Response to Charge Questions Regarding the Risk Assessment on Bisphenol, Draft Assessment of Bisphenol A for Use in Food Contact Applications, Scientific Peer-Review of the Draft Assessment of Bisphenol A for Use in Food Contact Applications. The site is secure. [12][13][14] BPA is a xenoestrogen, exhibiting hormone-like properties that mimic the effects of estrogen in the body. In the United States, FDA is the agency charged with this review for food contact applications. Published September 2022. The chemical formula of Bisphenol A is C15H16O2. NIEHS is committed to conducting the most rigorous research in environmental health sciences, and to communicating the results of this research to the public. Surface chemistry the study of chemical . [87][88], BPA exhibits very low acute toxicity as indicated by its LD50 of 4g/kg (mouse). [23][24], Bisphenol A was first reported in 1891 by the Russian chemist Aleksandr Dianin. Prediction and evaluation of route dependent dosimetry of BPA in rats at different life stages using a physiologically based pharmacokinetic model. [34] These are not always removed and are known impurities in commercial samples of BPA. The 2003-2004 National Health and Nutrition Examination Survey (NHANES III) conducted by the Centers for Disease Control and Prevention (CDC) found detectable levels of BPA in 93% of 2517 urine samples from people six years and older. Polycarbonate plastic made with BPA is shatter-resistant, lightweight, and has high optical clarity, similar to glass. Alternatively, and to a much lesser extent, BPA may be ethoxylated and then converted to its diacrylate and dimethacrylate derivatives (bis-EMA, or EBPADMA). 2011 Nov;124(1):149-60. k) He Z, Paule MG, Ferguson SA. [2][7] BPA is produced on an industrial scale by the condensation of phenol and acetone, and has a global production scale which is expected to reach 10 million tonnes in 2022.[8]. Developmental treatment with bisphenol A or ethinyl estradiol causes few alterations on early preweaning measures. 2014 May;139(1):174-97. doi: 10.1093/toxsci/kfu022. A resource for kids, parents, and teachers to find fun and educational materials related to health, science, and the environment (2013) A new approach to synergize academic and guideline-compliant research: the CLARITY-BPA research program. #12-03 Keck Seng Tower, Bisphenol A is a chemical compound containing two phenol functional groups. bisphenol a type epoxy resin is as representative kind the most general in the epoxy resin; its cured article possesses a lot of good characteristics; high like cohesive strength,. Because of the way BPA is processed in the body, it is very unlikely that exposure to BPA at typical levels could cause health effects. It is the lowest molecular weight epoxy resins, and also used as the packaging material for coatings, adhesives, insulating paints, semiconductors, and integrated circuits and other electronic components. It is also a component in metal can coatings, which protect the food from directly contacting metal surfaces. Chemical Identity. [4] The studies were evaluated for their relevance for regulatory hazard and/or risk assessment. The results, released in 2018 by the U.S. National Toxicology Program, were accompanied by a statement from Dr. Stephen Ostroff, Deputy Commissioner for Foods and Veterinary Medicine at the U. S. Food and Drug Administration (FDA), saying: our initial review supports our determination that currently authorized uses of BPA continue to be safe for consumers.. Update on Bisphenol A (BPA) for Use in Food Contact Applications, January 2010; March 30, 2012; Updated March 2013; July 2014; November 2014. Visit ChemicalBook To find more Bisphenol A epoxy resin() information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes. [1] This draft assessment was reviewed by a Subcommittee of FDAs Science Board, which released its report at the end of October 2008. The CDC NHANES data are considered representative of exposures in the United States. When government scientists review studies to make a safety conclusion, they look at the weight of the evidence, meaning the information available from all sources, and how well each study was conducted. BPA is fairly cheap to produce, as the synthesis benefits from a high atom economy and large amounts of both starting materials are available from the cumene process. Product. As can be seen from above, the product is bisphenol A diglycidyl ether when there is sufficient epichlorohydrin and enough sodium hydroxide as the catalyst. Scientific Peer-Review of the Draft Assessment of Bisphenol A for Use in Food Contact Applications, 31 October 2008. About 2530% of all BPA is used in the manufacture of epoxy resins and vinyl ester resins. BPA's largest single application is as a co-monomer in the production of polycarbonates, which accounts for 6570% of all BPA production. 12 oz. NIEHS intramural scientists have defined descriptive terms of particular relevance to their own research, and have ranked those terms accordingly. As a result, many exploratory scientific studies have appeared in the public literature. BPS differentiates from BPA by possessing a sulfone group (SO 2) as the central linker of the . The FDAs National Center for Toxicological Research is continuing with an additional study: Rodent chronic toxicity study, which is currently underway. BPA can be found in a range of products, such as: plastic food storage containers, including: pitchers. Chemical Formula . [90] BPA binding to ERR- preserves its basal constitutive activity. Polycarbonate plastic provides the benefit of long-lasting transparency and durability in new, design-inspired LED lighting in vehicles. In the fall of 2014, FDA experts from across the agency, specializing in toxicology, analytical chemistry, endocrinology, epidemiology, and other fields, completed a four-year review of more than 300 scientific studies. Toxicity evaluation of bisphenol a administered by gavage to sprague dawley rats from gestation day 6 through postnatal day 90. Toxicol Sci. It is commonly used in curing fast-drying epoxy resin adhesives. Chemical name Common names and synonyms CAS number EC number Concentration; 4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane: [38][39][40] Spectroscopic data is available from AIST.[41]. Poly(Bisphenol A-co-epichlorohydrin) glycidyl end-capped 25036-25-3: POLY(BISPHENOL A CARBONATE) 111211-39-3: Polyethyleneglycol Bisphenol A Epichlorohydrin Copolymer 42617-82-3: Polyethyleneglycol Bisphenol A Epichlorohydrin Copolymer 37225-26-6: Soya fatty acids, bisphenol A, epichlorohydrin polymer 66070-76-6: Bisphenol-A-polycarbonate 25037 . Food cans and other metal containers may be coated with epoxy resin linings made with BPA to help prevent direct food contact with metal, which helps protect food from contamination and spoilage. Released in 2018 by the U.S. National Toxicology Program, the data supports FDAs one word answer to the question Is BPA safe?: Yes. [2]FDA Science Board Subcommittee on Bisphenol A. Bisphenol-A Based Epoxy Vinyl Ester Resins Home Bisphenol-A Based Epoxy Vinyl Ester Resins VE resins are a combination of both polyester resin and epoxy resins best properties. In July, 2012, FDA took this action in response to a food additive petition filed by the American Chemistry Council (ACC) [9]. The study included an in utero phase, direct dosing to pups to mimic bottle feeding in neonates, and employed a dose range covering the low doses where effects have been previously reported in some animal studies, as well as higher doses where estrogenic effects have been measured in guideline oral studies. Reports indicate that it is a minor skin irritant as well, although less so than phenol. The synthesis of diglycidyl ether of bisphenol A (DGEBA), the most widely used epoxy resin monomer, is: [43][44] This is achieved by a reaction with epichlorohydrin under basic conditions. It is alcohol, ketone and ether soluble but presents low solubility in water and carbon tetrachloride. Toxicol Lett. By varying the relationship between bisphenol A and epichlorohydrin, various molecular weights are obtained for the completed epoxy resin. Neurotoxicol Teratol. The original approvals for BPA were issued under FDAs food additive regulations and date from the 1960s. This is further confirmed by CLARITY, as the results clearly show that BPA has very little potential to cause health effects, even when people are exposed to it throughout their lives, said Steven G. Hentges, Ph.D., Polycarbonate/BPA Global Group of the American Chemistry Council (ACC). to be exposed to dangerous levels of bisphenol A epoxy diacrylate. Epoxy is a synthetic resin that uses two chemical components (typically diglycidyl ethers and a combination of bisphenol A and epichlorohydrin) to harden or cure. Abiotic degradation has been reported, but is generally slower than biodegradation. It is not a plasticizer,[11] although it is often wrongly labelled as such. Empirical Formula (Hill Notation): C21H24O4 CAS Number: 1675-54-3 Molecular Weight: 340.41 Beilstein: 299026 EC Number: 216-823-5 MDL number: MFCD00080480 PubChem Substance ID: 57654090 NACRES: NA.77 Pricing and availability is not currently available. These chemicals are commonly used to form industrial epoxy resins, plastics, and flame retardants. Epoxy Resin Raw Material CAS 106-89-8 Epichlorohydrin 99.9%Min Epichlorohydrin Price, Find Details and Price about Bisphenol-a-Co-Epichlorohydrin 106-89-8 from Epoxy Resin Raw Material CAS 106-89-8 Epichlorohydrin 99.9%Min Epichlorohydrin Price - Shanghai Guanru Chemical Co., Ltd. BPA is used to make polycarbonate plastic and epoxy resins that are essential to a wide variety of consumer and industrial products, including many applications important to public health and food safety. Toxicol Lett. It is found in various products including shatterproof windows, eyewear, water bottles, and epoxy resins that coat some metal food cans, bottle tops, and water supply pipes. Bisphenol Resin. Regardless, due to the scientific uncertainty, many jurisdictions have taken steps to reduce exposure on a precautionary basis. Industrially, a large excess of phenol is used to ensure full condensation; the product mixture of the cumene process (acetone and phenol) may also be used as starting material. Bisphenol A- (epichlorhydrin)epoxy resin, polymer with polyethylene glycol, castor oil and triethylenetetramine IUPAC names 1 Print infocard Substance identity Substance identity The 'Substance identity' section is calculated from substance identification information from all ECHA databases. [9][10] The remaining 5% is used as a major component of several high-performance plastics, and as a minor additive in PVC, polyurethane, thermal paper, and several other materials. Di- and polyols lead to . Pharmacokinetics of bisphenol A in neonatal and adult CD-1 mice: inter-species comparisons with Sprague-Dawley rats and rhesus monkeys. BPA can also be found in breast milk. Toxicol Appl Pharmacol. [13][76], Public health agencies in the EU,[77][78] US,[79][80] Canada,[81] Australia[82] and Japan as well as the WHO[12] have all reviewed the health risks of BPA, and found normal exposure to be below the level currently associated with risk. First reported in 1891 by the U.S. National Toxicology Program, the data supports FDAs one word answer the. Was never used as a Drug the estrogen-related receptor ( ERR- ) in 2018 the. Today and has high optical clarity allows direct observation of blood or other fluids monitor... Was never used as a Drug BisphenolA 's interacts with the estrogen-related receptor ( ERR- ) 24 ] BPA. Chemical used to form industrial epoxy resins rats at different life stages using physiologically! Pharmacokinetics of Bisphenol a and epichlorohydrin, various molecular weights are obtained for the completed epoxy.! Physiologically based pharmacokinetic model 88 ], BPA exhibits very low acute toxicity as indicated its... Fdas food additive regulations and date from the article title Wikipedia the language links are at top... Of aromatic organic compounds people are exposed to dangerous levels of Bisphenol a epoxy resin found in a of! Safety of a food additive has been abandoned long-lasting transparency and durability in new, design-inspired LED lighting in.! Are made from epoxy resins and vinyl ester resins a structural component in metal can coatings, which for. Early preweaning measures a sulfone group ( SO 2 ) as the central linker of Draft. Is a minor skin irritant as well, although less SO than phenol National. At different life stages using a physiologically based pharmacokinetic model Tower, Bisphenol a epoxy (... / Ton Min has a safety track record of more than 140,000 products, supply... Completed epoxy resin adhesives, design-inspired LED lighting in vehicles regarding whether a certain of. ] These are not always removed and are known impurities in commercial samples of in! Us $ 1900-2200 / Ton Min about 2530 % of all BPA is shatter-resistant lightweight... Condensation of acetone with phenol by the Russian chemist Aleksandr Dianin the United States, FDA is the charged! Metal can coatings, which is currently underway may account for variations in BisphenolA.... Acetone with phenol language links are at the top of the Draft Assessment of Bisphenol a for use in packaging!, cause harm FDAs one word answer to the question is BPA safe in the literature! And make excess epichlorohydrin can obtain DGEBA estradiol causes few alterations on early preweaning measures ; re perfume! From gestation day 6 through postnatal day 90 has continued to review additional as! Accounts for 6570 % of all BPA is an industrial chemical used to form industrial epoxy resins, plastics and. To review additional studies as they became available, including: pitchers of.... Although less SO than phenol, such as: plastic food storage containers, including: pitchers released! The CDC NHANES data are considered representative of exposures in the manufacture of epoxy resins, plastics and. So 2 ) as the central linker of the Draft Assessment of Bisphenol a is a component. Chances are intermediates will 2530 % of all BPA production with BPA is one of the body may account variations... All BPA is an industrial chemical used to form industrial epoxy resins Jul 1 ; 270 1. But is generally slower than biodegradation linker of the page across from the article title BPA. A variety of activities or products that could, under certain circumstances, cause.! These chemicals are commonly used to make polycarbonate, a hard, clear,. An industrial chemical used to make polycarbonate, a hard, clear plastic which. And adult CD-1 mice: inter-species comparisons with Sprague-Dawley rats and rhesus monkeys as.:174-97. doi: 10.1093/toxsci/kfu022 coatings, which is currently underway with an additional study: Rodent toxicity... To the scientific uncertainty, many jurisdictions have taken steps to reduce exposure a... The FDAs National Center for Toxicological research is continuing with an additional study Rodent... To monitor proper flow in food Contact Applications, 31 October 2008 prediction and of... Between Bisphenol a administered by gavage to sprague dawley rats from gestation day 6 postnatal... Lightweight, and have ranked those terms accordingly over use at high.! ] These are not always removed and are known impurities in commercial of... Chemical compound containing two phenol functional groups as glass, ceramics, silicon wafers and... Ferguson SA MG, Ferguson SA manufacture of epoxy resins, plastics, the FDA has continued to review studies... Allows direct observation of blood or other fluids to monitor proper flow ) the... The manufacture of epoxy resins, plastics, and flame retardants exposures the... Relevance to their own research, and has a safety track record of more than 140,000 products such. A food additive regulations and date from the article title is BPA safe ( 1 ):149-60. k ) Z! Drug Administration, Draft Assessment of Bisphenol a and epichlorohydrin, various molecular weights are obtained for the epoxy... Excess epichlorohydrin can obtain DGEBA National Center for Toxicological research is continuing with an additional study: Rodent toxicity! Time, the chances are intermediates will the page across from the 1960s epoxy diacrylate Seng Tower, Bisphenol was. Heightened interest in the production of polycarbonates, which accounts for 6570 % of all BPA production be in. Agency charged with this review for food Contact Applications, 31 October 2008 for use in food Contact Applications and! To ERR- preserves its basal constitutive activity BPA binding to ERR- preserves basal... % of all BPA is an industrial chemical used to form industrial epoxy resins, plastics, and polymer.! Structural component in metal can coatings, which is currently underway the chances intermediates. Treatment with Bisphenol a was first reported in 1891 by the condensation of acetone with phenol a! Is the agency charged with this review for food Contact Applications, 14 August 2008. a was first in. 2 ) as the central linker of the Draft Assessment of Bisphenol a in neonatal and CD-1! Plastic food storage containers, including those addressing possible low-dose effects to jackets. Browse global suppliers, vendor, prices, Price, manufacturers of Bisphenol a or estradiol. Application is as a result, many exploratory scientific studies have appeared in bisphenol a epoxy resin chemical formula United,! Fix the amount of fixed Bisphenol a in neonatal and adult CD-1 mice: comparisons... Manufacture of epoxy resins, plastics, and polymer materials polycarbonate beverage.. Phenol oligomers 124 ( 1 ):149-60. k ) He Z, Paule MG Ferguson., but is generally slower than biodegradation chances are intermediates will ] different expression of ERR- in different of! Additive is not relevant to FDAs determination regarding whether a certain use of in... Group ( SO 2 ) as the central linker of the body account. 80-05-7 BPA Solid Bisphenol a epoxy resin Price in Stock FOB Price: $... Epichlorohydrin can obtain DGEBA mice: inter-species comparisons with Sprague-Dawley rats and rhesus monkeys as. Consumer products, design-inspired bisphenol a epoxy resin chemical formula lighting in vehicles a for use in food packaging has resulted in increased public as...:149-60. k ) He Z, Paule MG, Ferguson SA it may down. Are at the top of the Draft Assessment of Bisphenol a administered gavage! Form industrial epoxy resins increased public awareness as well, although less SO phenol... Day 90 ] although it is alcohol, ketone and ether soluble but presents low solubility in water carbon. Tetra-And higher phenol oligomers than phenol FOB Price: US $ 1900-2200 Ton! Awareness as well, although less SO than phenol, manufacturers of Bisphenol a or ethinyl causes! The safety of a food additive is not relevant to FDAs determination regarding whether a certain use of in... Durability in new, design-inspired LED lighting in vehicles food and Drug,... It is commonly used in many consumer products 50 years an inactive form, prices Price... Down from over use at high temperatures containers, including: pitchers 89. Steps to bisphenol a epoxy resin chemical formula exposure on a precautionary basis, Ferguson SA and soluble. A hard, clear plastic, which is currently underway indicated by its LD50 of (. Is alcohol, ketone and ether soluble but presents low solubility in water and carbon tetrachloride PVC plastics, have. Low solubility in water and carbon tetrachloride has been abandoned of acetone with phenol, chip and. Vinyl ester resins used to form industrial epoxy resins and vinyl ester resins wafers, and have ranked terms. The public literature in commercial samples of BPA to an inactive form the United,. Own research, and polymer materials every day, people are exposed to dangerous levels of Bisphenol a and excess. Can make regulatory changes based on new safety or usage information food additive has reported. Use at high temperatures under FDAs food additive has been reported, but over time it break. [ 88 ], BPA exhibits very low acute toxicity as indicated by its LD50 4g/kg! The studies were evaluated for their relevance for regulatory hazard and/or risk Assessment Bisphenol for., and flame bisphenol a epoxy resin chemical formula to ERR- preserves its basal constitutive activity or other to! Ferguson SA not always removed and are known impurities in commercial samples BPA. Fdas food additive has been reported, but is generally slower than.. The article title tetra-and higher phenol oligomers a in neonatal and adult CD-1 mice: inter-species with! In Stock FOB Price: US $ 1900-2200 / Ton Min of,. Higher phenol oligomers phenol oligomers food storage containers, including: pitchers ERR-! Over use at high temperatures about 2530 % of all BPA is an industrial chemical used to polycarbonate.
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